abstract：BACKGROUND:RECORD-3 assessed non-inferiority of progression-free survival (PFS) with everolimus vs sunitinib in previously untreated patients with metastatic renal cell carcinoma. Baseline plasma sample collection and randomised design enabled correlation of circulating biomarkers with efficacy. METHODS:Samples were a...

journal_title：British journal of cancer

authors： Voss MH,Chen D,Marker M,Hakimi AA,Lee CH,Hsieh JJ,Knox JJ,Voi M,Motzer RJ

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Ovarian and endometrial high-grade serous carcinomas (HGSCs) have similar clinical and pathological characteristics; however, exhaustive protein expression profiling of these cancers has yet to be reported. METHODS:We performed protein expression profiling on 14 cases of HGSCs (7 ovarian and 7 endometrial) ...

journal_title：British journal of cancer

authors： Hiramatsu K,Yoshino K,Serada S,Yoshihara K,Hori Y,Fujimoto M,Matsuzaki S,Egawa-Takata T,Kobayashi E,Ueda Y,Morii E,Enomoto T,Naka T,Kimura T

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:To document the effect of bivalent HPV immunisation on cervical cytology as a screening test and assess the implications of any change, using a retrospective analysis of routinely collected data from the Scottish Cervical Screening Programme (SCSP). METHODS:Data were extracted from the Scottish Cervical Cal...

journal_title：British journal of cancer

authors： Palmer TJ,McFadden M,Pollock KG,Kavanagh K,Cuschieri K,Cruickshank M,Cotton S,Nicoll S,Robertson C

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Lithium accumulates in the colon and inhibits the enzyme GSK-3β that possesses anti-carcinogenic effects. We therefore examined the association between lithium use and colorectal cancer risk in a nationwide study. METHODS:We used the Danish Cancer Registry to identify all patients diagnosed with incident co...

journal_title：British journal of cancer

authors： Pottegård A,Ennis ZN,Hallas J,Jensen BL,Madsen K,Friis S

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:This study had two aims: (a) to test the hypothesis that advanced age is associated with lower levels of tolerability and clinical benefit to experimental Phase I trial agents; (b) to assess the validity of the Royal Marsden Hospital (RMH) prognostic score as a patient selection tool in older patients. METH...

journal_title：British journal of cancer

authors： Khan KH,Yap TA,Ring A,Molife LR,Bodla S,Thomas K,Zivi A,Smith A,Judson I,Banerji U,de Bono JS,Kaye SB

更新日期：2016-02-02 00:00:00

abstract：BACKGROUND:Increased survival after cancer in young age has made long-term follow-up studies of high external validity important. In this national cohort study, we explored the impact of cancer in young age on reproduction and marital status in male survivors. METHODS:Hazard ratios (HRs) and relative risks (RRs) of re...

journal_title：British journal of cancer

authors： Gunnes MW,Lie RT,Bjørge T,Ghaderi S,Ruud E,Syse A,Moster D

更新日期：2016-02-02 00:00:00

abstract：BACKGROUND:Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer (PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway that may mediate this interaction is the HGF-c-MET pathway. METHODS:Effects of HGF inhibition (using a neutralising antibody AMG102) alon...

journal_title：British journal of cancer

authors： Pothula SP,Xu Z,Goldstein D,Biankin AV,Pirola RC,Wilson JS,Apte MV

更新日期：2016-02-02 00:00:00

abstract：BACKGROUND:Regulator of cullins-1 (ROC1) is a key subunit in the cullin-RING ligase (CRL) protein complex. Our previous study indicated that ROC1 was essential for bladder cancer cell survival and that ROC1 knockdown inhibited CRL activity, triggering G2 phase arrest and senescence. However, the role of ROC1 in the mal...

journal_title：British journal of cancer

authors： Wang W,Chen H,Liu Z,Qu P,Lan J,Chen H,Zou L,Qiu J

更新日期：2016-02-02 00:00:00

abstract：BACKGROUND:CD70 is a costimulatory molecule of the tumour necrosis factor family expressed in activated immune cells and some solid tumours. In lymphocytes CD70 triggers T cell-mediated cytotoxicity and mitogen-activated protein kinase phosphorylation. METHODS:We evaluated the expression of CD70 in biopsies and melano...

journal_title：British journal of cancer

authors： Pich C,Sarrabayrouse G,Teiti I,Mariamé B,Rochaix P,Lamant L,Favre G,Maisongrosse V,Tilkin-Mariamé AF

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS:Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nucle...

journal_title：British journal of cancer

authors： Chan AW,Mercier P,Schiller D,Bailey R,Robbins S,Eurich DT,Sawyer MB,Broadhurst D

更新日期：2016-01-12 00:00:00

abstract：BACKGROUND:To date, no adjuvant treatment has been shown to have a clear benefit in patients with hepatocellular carcinoma (HCC). In this prospective phase I/IIa study, we evaluated the safety and efficacy of adjuvant dendritic cell (DC) therapy in HCC patients who received primary treatment for HCC. METHODS:Twelve HC...

journal_title：British journal of cancer

authors： Lee JH,Lee Y,Lee M,Heo MK,Song JS,Kim KH,Lee H,Yi NJ,Lee KW,Suh KS,Bae YS,Kim YJ

更新日期：2015-12-22 00:00:00

abstract：BACKGROUND:Activated anaplastic lymphoma kinase (ALK) gene fusions are recurrent events in a small fraction of colorectal cancers (CRCs), although these events have not yet been exploited as in other malignancies. METHODS:We detected ALK protein expression by immunohistochemistry and gene rearrangements by fluorescenc...

journal_title：British journal of cancer

authors： Amatu A,Somaschini A,Cerea G,Bosotti R,Valtorta E,Buonandi P,Marrapese G,Veronese S,Luo D,Hornby Z,Multani P,Murphy D,Shoemaker R,Lauricella C,Giannetta L,Maiolani M,Vanzulli A,Ardini E,Galvani A,Isacchi A,Sartore

更新日期：2015-12-22 00:00:00

abstract：:Ovarian cancer is the fifth leading cause of female cancer deaths in the Western world. Significant progress has been made in the treatment of patients with ovarian cancer, however, the majority of patients experience disease recurrence and new therapies are being sought for such patients. Clinical investigation of po...

journal_title：British journal of cancer

authors： Ledermann JA,El-Khouly F

更新日期：2015-12-15 00:00:00

abstract：:Metabolic reprogramming towards aerobic glycolysis is a common feature of transformed cells and can be driven by a network of transcription factors. It is well established that c-Myc and hypoxia-inducible factor-1α (HIF-1α) contribute to metabolic reprogramming by driving the expression of glycolytic target genes. Mor...

journal_title：British journal of cancer

authors： Wilde BR,Ayer DE

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:We performed a retrospective nationwide study to explore age as a prognostic factor in synovial sarcoma patients. METHODS:Data on 613 synovial sarcoma patients were obtained from the Netherlands Cancer Registry. The prognostic relevance of age groups (children, adolescent and young adults (AYAs), adults, an...

journal_title：British journal of cancer

authors： Vlenterie M,Ho VK,Kaal SE,Vlenterie R,Haas R,van der Graaf WT

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Early detection of non-small-cell lung cancer (NSCLC) and accurate prognostic risk assessment could improve patient outcome. We examined the significance of urinary N(1), N(12)-diacetylspermine (DiAcSpm) in the detection and prognostic stratification of NSCLC patients. METHODS:A DiAcSpm/cutoff ratio (DASr) ...

journal_title：British journal of cancer

authors： Takahashi Y,Sakaguchi K,Horio H,Hiramatsu K,Moriya S,Takahashi K,Kawakita M

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Lapatinib, a dual EGFR and HER2 inhibitor has shown disappointing results in clinical trials of metastatic oesophago-gastric adenocarcinomas (OGAs), and in vitro studies suggest that MET, IGFR, and HER3 confer resistance. This trial applied Lapatinib in the curative neoadjuvant setting and investigated the f...

journal_title：British journal of cancer

authors： De Silva N,Schulz L,Paterson A,Qain W,Secrier M,Godfrey E,Cheow H,O'Donovan M,Lao-Sirieix P,Jobanputra M,Hochhauser D,Fitzgerald R,Ford H

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:It is known that cancer stage is affected by comorbidity, but the evidence regarding the magnitude and even direction of this effect is highly inconsistent and poorly understood. The aims of this study were to establish the impact of comorbidity on cancer stage at diagnosis, using both specific individual co...

journal_title：British journal of cancer

authors： Gurney J,Sarfati D,Stanley J

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:Recently, many studies have suggested a possible adjuvant role of aspirin in colorectal cancer, reporting a positive prognostic effect with its use in patients with established disease. The aim of this study was to investigate the anticancer effect of aspirin use during preoperative chemoradiation for rectal...

journal_title：British journal of cancer

authors： Restivo A,Cocco IM,Casula G,Scintu F,Cabras F,Scartozzi M,Zorcolo L

更新日期：2015-10-20 00:00:00

abstract：BACKGROUND:Inconsistencies between mitotic index (MI) and Ki67 measures have been identified in many breast tumour samples. The aim of this study was to describe the prognosis of hormone receptor-positive (HR+) HER2- tumours having discrepant MI and Ki67. METHODS:We included a cohort of breast cancer patients initiall...

journal_title：British journal of cancer

authors： Rossi L,Laas E,Mallon P,Vincent-Salomon A,Guinebretiere JM,Lerebours F,Rouzier R,Pierga JY,Reyal F

更新日期：2015-09-29 00:00:00

abstract：BACKGROUND:Low cancer awareness may contribute to delayed diagnosis and poor cancer survival. We aimed to quantify socio-demographic differences in cancer symptom awareness and barriers to symptomatic presentation in the English population. METHODS:Using a uniquely large data set (n=49 270), we examined the associatio...

journal_title：British journal of cancer

authors： Niksic M,Rachet B,Warburton FG,Wardle J,Ramirez AJ,Forbes LJ

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Most oestrogen receptor (ER)-positive early breast cancer diagnosed today is highly curable with multimodality treatment. Systemic adjuvant treatments including endocrine therapy and chemotherapy have made a significant contribution to the increasing cure rates over the past three decades. However not all wo...

journal_title：British journal of cancer

authors： Yeo B,Zabaglo L,Hills M,Dodson A,Smith I,Dowsett M

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:The natural history of prostate cancer is highly variable and difficult to predict accurately. Better markers are needed to guide management and avoid unnecessary treatment. In this study, we validate the prognostic value of a cell cycle progression score (CCP score) independently and in a prespecified linea...

journal_title：British journal of cancer

authors： Cuzick J,Stone S,Fisher G,Yang ZH,North BV,Berney DM,Beltran L,Greenberg D,Møller H,Reid JE,Gutin A,Lanchbury JS,Brawer M,Scardino P

更新日期：2015-07-28 00:00:00

abstract：BACKGROUND:Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. ME...

journal_title：British journal of cancer

authors： Sgaramella N,Coates PJ,Strindlund K,Loljung L,Colella G,Laurell G,Rossiello R,Muzio LL,Loizou C,Tartaro G,Olofsson K,Danielsson K,Fåhraeus R,Nylander K

更新日期：2015-07-14 00:00:00

abstract：BACKGROUND:MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC protein expression in neuroblastoma. METHODS:Immunostaining for MYCN and MYC protein was performed o...

journal_title：British journal of cancer

authors： Wang LL,Teshiba R,Ikegaki N,Tang XX,Naranjo A,London WB,Hogarty MD,Gastier-Foster JM,Look AT,Park JR,Maris JM,Cohn SL,Seeger RC,Asgharzadeh S,Shimada H

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:Recent studies have indicated the prognostic value of tumour subtype and pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). However these results were reported after a short follow-up and using a standard Cox model which could be unsatisfactory for time-dependent factors. In the prese...

journal_title：British journal of cancer

authors： Baulies S,Belin L,Mallon P,Senechal C,Pierga JY,Cottu P,Sablin MP,Sastre X,Asselain B,Rouzier R,Reyal F

更新日期：2015-06-30 00:00:00

abstract：BACKGROUND:The mitogen-activated protein kinase (MAPK) pathway has been implicated in the molecular pathogenesis of human cancers, including metastatic colorectal cancer (mCRC). This provides a rationale for the development of MAPK-targeted agents such as pimasertib. METHODS:Patients with KRAS mutant mCRC were treated...

journal_title：British journal of cancer

authors： Macarulla T,Cervantes A,Tabernero J,Roselló S,Van Cutsem E,Tejpar S,Prenen H,Martinelli E,Troiani T,Laffranchi B,Jego V,von Richter O,Ciardiello F

更新日期：2015-06-09 00:00:00

abstract：BACKGROUND:Some components of the Mediterranean diet have favourable effects on endometrial cancer, and the Mediterranean diet as a whole has been shown to have a beneficial role on various neoplasms. METHODS:We analysed this issue pooling data from three case-control studies carried out between 1983 and 2006 in vario...

journal_title：British journal of cancer

authors： Filomeno M,Bosetti C,Bidoli E,Levi F,Serraino D,Montella M,La Vecchia C,Tavani A

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:Identification of promising biomarkers that predict the prognosis of patients with breast cancer is needed. In this study, we hypothesised that the expression of the epithelial-mesenchymal transition-related biomarker plastin3 (PLS3) in peripheral blood could be a prognostic factor in breast cancer. METHODS...

journal_title：British journal of cancer

authors： Ueo H,Sugimachi K,Gorges TM,Bartkowiak K,Yokobori T,Müller V,Shinden Y,Ueda M,Ueo H,Mori M,Kuwano H,Maehara Y,Ohno S,Pantel K,Mimori K

更新日期：2015-04-28 00:00:00

abstract：BACKGROUND:In 2006, the National Health Service Bowel Cancer Screening Programme in England (NHSBCSP) began offering routine population-based biennial faecal occult blood testing (FOBt) at ages 60-69. There is, however, limited information on how characteristics of individuals affect participation and outcomes of scree...

journal_title：British journal of cancer

authors： Blanks RG,Benson VS,Alison R,Brown A,Reeves GK,Beral V,Patnick J,Green J

更新日期：2015-04-28 00:00:00

abstract：BACKGROUND:Accurate assessment of the prevalence of the human papilloma virus (HPV) in oropharyngeal tumours (OpSCC) is important because HPV-positive OpSCC are consistently associated with an improved overall survival. Recently, an algorithm has become available that reliably detects clinically relevant HPV in tumour ...

journal_title：British journal of cancer

authors： Melchers LJ,Mastik MF,Samaniego Cameron B,van Dijk BA,de Bock GH,van der Laan BF,van der Vegt B,Speel EJ,Roodenburg JL,Witjes MJ,Schuuring E

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...

journal_title：British journal of cancer

authors： Crespo M,van Dalum G,Ferraldeschi R,Zafeiriou Z,Sideris S,Lorente D,Bianchini D,Rodrigues DN,Riisnaes R,Miranda S,Figueiredo I,Flohr P,Nowakowska K,de Bono JS,Terstappen LW,Attard G

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case-control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associ...

journal_title：British journal of cancer

authors： Bamia C,Lagiou P,Jenab M,Aleksandrova K,Fedirko V,Trichopoulos D,Overvad K,Tjønneland A,Olsen A,Clavel-Chapelon F,Boutron-Ruault MC,Kvaskoff M,Katzke VA,Kühn T,Boeing H,Nöthlings U,Palli D,Sieri S,Panico S,Tumino R

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Appreciating variation in the length of pre- or post-presentation diagnostic intervals can help prioritise early diagnosis interventions with either a community or a primary care focus. METHODS:We analysed data from the first English National Audit of Cancer Diagnosis in Primary Care on 10 953 patients with...

journal_title：British journal of cancer

authors： Lyratzopoulos G,Saunders CL,Abel GA,McPhail S,Neal RD,Wardle J,Rubin GP

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Although inequalities in cancer survival are thought to reflect inequalities in stage at diagnosis, little evidence exists about the size of potential survival gains from eliminating inequalities in stage at diagnosis. METHODS:We used data on patients diagnosed with malignant melanoma in the East of England...

journal_title：British journal of cancer

authors： Rutherford MJ,Ironmonger L,Ormiston-Smith N,Abel GA,Greenberg DC,Lyratzopoulos G,Lambert PC

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:Factors related to early stimulation of the immune system (breastfeeding, proxies for exposure to infectious agents, normal delivery, and exposure to animals in early life) have been suggested to decrease the risk of childhood acute lymphoblastic leukaemia (ALL). METHODS:The national registry-based case-con...

journal_title：British journal of cancer

authors： Ajrouche R,Rudant J,Orsi L,Petit A,Baruchel A,Lambilliotte A,Gambart M,Michel G,Bertrand Y,Ducassou S,Gandemer V,Paillard C,Saumet L,Blin N,Hémon D,Clavel J

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...

journal_title：British journal of cancer

authors： Péron J,Roy P,Ding K,Parulekar WR,Roche L,Buyse M

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:MiR-125b has critical role in non-small-cell lung cancer (NSCLC) cell migration, and its target genes have not been elucidated. Kinesin-1 light chain (KLC)-2 was predicted as one of miR-125b's targets by bioinformatics analysis. This study is to identify the function of KLC2 and its interaction with miR-125b...

journal_title：British journal of cancer

authors： Wang M,Zhu X,Sha Z,Li N,Li D,Chen L

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:LGR5 is an important marker of intestinal stem cells and performs its vital functions at the cell membrane. Despite the importance of LGR5 to both normal and cancer stem cell biology, it is not known how microenvironmental stress affects the expression and subcellular distribution of the protein. METHODS:Nu...

journal_title：British journal of cancer

authors： Morgan RG,Molnár E,Jones RF,Collard TJ,Lane JD,Greenhough A,Paraskeva C,Williams AC

更新日期：2015-02-17 00:00:00

abstract：BACKGROUND:Systemic inflammatory response (SIR) is important in the relationship between the tumour, the host, and outcome in cancer patients. However, limited data exist regarding the prognostic significance of SIR in bladder cancer. We investigate the utility of pretreatment SIR in patients with urothelial carcinoma ...

journal_title：British journal of cancer

authors： Ku JH,Kang M,Kim HS,Jeong CW,Kwak C,Kim HH

更新日期：2015-02-03 00:00:00